Figure 1
From: The role of caveolin-1 in prostate cancer: clinical implications
Caveolin-1 (cav-1) upregulation in prostate cancer promotes cell survival through Akt-mediated activities. Prostate cancer-derived, secreted cav-1, which is taken up by prostate cancer cells and tumor-associated endothelial cells, stimulates angiogenesis. The unique autocrine and paracrine activities associated with cav-1 in prostate cancer present a novel paradigm for the development of biomarkers and therapeutic approaches for prostate cancer. GFs, growth factors; ACs, angiogenic cytokines; AR, androgen receptor.
