Table 2 Outcomes in patients with and without visceral disease at baseline
Outcome | Patients with visceral disease | Patients without visceral disease | ||||
|---|---|---|---|---|---|---|
AA+ P (n=253) | P (n=99) | P-value | AA+P (n=544) | P (n=299) | P-value | |
Overall survival | ||||||
Median, months | 12.9 | 8.3 | 0.1022 | 17.1 | 12.3 | <0.0001 |
HR (95% CI) | 0.79 (0.60–1.05) | 0.69 (0.58–0.83) | ||||
Radiographic progression-free survival | ||||||
Median, months | 5.6 | 2.8 | 0.0002 | 5.9 | 5.1 | <0.0001 |
HR (95% CI) | 0.60 (0.46–0.78) | 0.68 (0.58–0.80) | ||||
PSA response rate, % | 28 | 7 | <0.0001 | 30 | 5 | <0.0001 |
Objective response rate, % | 11 | 0 | 0.0058 | 19 | 5 | 0.0010 |
Relative risk (95% CI) | NE | 3.51 (1.53–8.04) | ||||
