Figure 4

Receiver operating characteristic (ROC) curves for 5-year survival prediction. Prediction of survival time was modeled using a parametric model based on the assumption of the Weibull distribution. ROC curves at 5-year survival prediction show the sensitivity and the specificity of survival prediction. Overall (upper panel), PCa-specific (middle panel) and non-PCa-specific survival (bottom panel) predictions at 5 years were determined by the clinical parameters alone (black lines), and by both clinical parameters and the tumor subtypes classified by embryonic stem cell gene predictor (ESCGP) signature (red lines). The area under the curve (AUC) values of overall, PCa-specific and non-PCa-specific survival predictions were all increased by adding ESCGP signature. Positive predictive value (PPV) and negative predictive value (NPV) both increased.