Table 1 Clinical and pathological features of men who underwent radical prostatectomy

From: Obesity and prostate cancer-specific mortality after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database

 

Normal weight

Overweight

Obese

P-value

 

BMI<25 kg/m 2

25⩽BMI<30 kg/m 2

BMI⩾30 kg/m 2

 

No. patients, n (%)

955 (22)

1941 (45)

1372 (32)

–

Age, mean±s.d.

62.5±6.3

62.1±6.2

61.2±6.1

<0.001 a

Race, n (%)b

   

0.119c

 White

549 (58)

1190 (62)

794 (58)

 

 Black

373 (39)

675 (35)

529 (39)

 

 Other

29 (3)

60 (3)

37 (3)

 

Center, n (%)

   

<0.001 c

 Center A

223 (23)

459 (24)

234 (17)

 

 Center B

104 (11)

238 (12)

158 (11)

 

 Center C

162 (17)

352 (18)

288 (21)

 

 Center D

203 (21)

358 (18)

301 (22)

 

 Center E

145 (15)

307 (16)

233 (17)

 

 Center F

118 (12)

227 (12)

158 (12)

 

Year of surgery

   

<0.001 d

 Median (Q1–Q3)

2005 (2000–2010)

2006 (2002–2011)

2007 (2003–2011)

 

PSA (ng ml−1)

   

<0.001 d

 Median (Q1–Q3)

7.1 (5.0–11.1)

6.3 (4.7–9.5)

6.1 (4.7–9.0)

 

Clinical stage, n (%)b

   

0.093c

 T1

543 (59)

1141 (61)

843 (63)

 

 T2–T4

381 (41)

741 (39)

491 (37)

 

Biopsy Gleason sum, n (%)

   

0.003 c

 2–6

503 (53)

893 (46)

610 (44)

 

 3+4

241 (25)

516 (27)

393 (29)

 

 4+3

97 (10)

260 (13)

170 (12)

 

 8–10

114 (12)

272 (14)

199 (14)

 

Pathological Gleason sum, n (%)

   

0.028 c

 2–6

319 (33)

603 (31)

378 (28)

 

 3+4

366 (38)

715 (37)

561 (41)

 

 4+3

153 (16)

335 (17)

242 (18)

 

 8–10

117 (12)

288 (15)

191 (14)

 

Positive surgical margins, n (%)

368 (39)

757 (39)

573 (42)

0.186c

Extracapsular extension, n (%)

181 (19)

396 (20)

259 (19)

0.472c

Seminal vesicle invasion, n (%)

93 (10)

209 (11)

138 (10)

0.647c

Positive lymph nodes, n (%)

   

0.480c

 No

616 (65)

1253 (65)

846 (62)

 

 Yes

22 (2)

47 (2)

33 (2)

 

 Not done

317 (33)

641 (33)

493 (36)

 

Follow-up time (years) e

   

0.050d

 Median (Q1–Q3)

7.0 (3.5–11.2)

7.0 (3.6–11.2)

6.3 (3.3–10.6)

 
  1. Abbreviation: BMI, body mass index.
  2. aP-value calculated using analysis of variance test.
  3. bRace was missing on 4 normal weight, 16 overweight and 12 obese men. Clinical stages were missing on 31 normal weight men, 59 overweight men and 38 obese men.
  4. cP-value calculated using χ2 test.
  5. dP-value calculated using Kruskal–Wallis test.
  6. eFollow-up time was calculated on men who did not die. The bold numbers indicate that the associations are significant.
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