Table 3 Hazard ratios for the associations between BMI and secondary treatment after radical prostatectomy

From: Obesity and prostate cancer-specific mortality after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database

 

ADT

XRT

 

N

HR

95% CI

P-value

N

HR

95% CI

P-value

Unadjusted

 BMI

667/4268

1.01

1.00–1.03

0.112

968/4268

1.03

1.01–1.04

<0.001

 BMI category

        

Normal

144/955

1.00

Ref

–

199/955

1.00

Ref

–

Overweight

302/1941

1.04

0.84–1.28

0.722

432/1941

1.09

0.92–1.29

0.316

Obese

221/1372

1.12

0.90–1.39

0.331

337/1372

1.25

1.05-1.49

0.012

Multivariable a

 BMI

667/4268

1.02

1.00–1.04

0.012

968/4252

1.02

1.01–1.04

<0.001

 BMI category

        

Normal

144/955

1.00

Ref

–

198/945

1.00

Ref

–

Overweight

302/1941

1.12

0.91–1.38

0.273

432/1938

1.08

0.91–1.28

0.357

Obese

221/1372

1.26

1.01–1.58

0.044

338/1369

1.24

1.04–1.48

0.018

Multivariable b

 BMI

667/4268

1.01

1.00–1.03

0.077

968/4252

1.02

1.01–1.03

0.004

 BMI category

        

Normal

144/955

1.00

Ref

–

198/945

1.00

Ref

–

Overweight

302/1941

1.08

0.87–1.33

0.494

432/1938

1.05

0.89–1.24

0.566

Obese

221/1372

1.19

0.95–1.49

0.132

338/1369

1.15

0.97–1.38

0.117

  1. Abbreviations: ADT, androgen-deprivation therapy; BMI, body mass index; CI, confidence interval; HR, hazard ratio; XRT, radiation therapy.
  2. aAdjusted for clinical characteristics: age, PSA, biopsy Gleason score, surgical center and year of surgery.
  3. bAdjusted for clinical and pathological characteristics: age, PSA, year of surgery, surgical center, pathological Gleason score, positive margins, extracapsular extension, seminal vesicles and lymph node involvement. The bold numbers indicate that the associations are significant.
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