Abstract
Random copolymers, poly(N-hydroxyethyl L-glutamine-co-N-hydroxypentyl L-glutamine) (PHPeEG) and poly(N-hydroxypropyl L-glutamine-co-N-hydroxypentyl L-glutamine) (PHPePG) as well as the corresponding homopolymers, poly(N-hydroxyethyl L-glutamine) (PHEG), poly(N-hydroxypropyl L-glutamine) (PHPG), and poly(N-hydroxypenthyl L-glutamine) (PHPeG), were prepared by aminolysis in the presence of the crosslinking agent, octamethylenediamine (OMDA), of a membrane of poly(γ-benzyl-L-glutamate). Membrane properties, such as the degree of swelling Qw, conformational property, tensile property, water vapor permeability and enzymatic degradation behavior were studied in the pseudo-extracellular fluid (PECF). Qw and molecular conformation are dependent on the composition of random copolymers. The mechanical strength of PHEG and PHPG hydrogels has been improved largely by introducing HPeG residues. Suitable mechanical property and water vapor permeability were obtained in some copolymers, which were compatible as skin substitutes. When compared at the same Qw, PHPePG copolymers were shown to have higher helix content and mechanical strength, lower water vapor permeability and faster papain digestion than PHPeEG copolymers. This can be explained by differences in hydrophobicity between PHEG and PHPG.
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Nakanishi, E., Shimizu, Y., Ogura, K. et al. Effects of Side Chain Length on Membrane Properties of Copoly(N-hydroxyalkyl L-glutamine) Hydrogels. Polym J 23, 1061–1068 (1991). https://doi.org/10.1295/polymj.23.1061
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DOI: https://doi.org/10.1295/polymj.23.1061
