Abstract
Crosslinked carboxymethylpullulan have been synthesized by using the dibromohexan as a crosslinking agent. Two phases are obtained after synthesis: a gel and a sol fraction. The sol/gel ratio is dependent on the variation of the polymer concentration (Cp), the incorporation ratio of the dibromohexan (Rc) and the average molar mass (Mn). The study of the swelling degree in water of the gel fraction has shown that this phase is not stable and that it shrinks after a certain time. This phenomenon is accelerated by an increase in temperature. At a macroscopic level, the gelation point is not reached. Nevertheless, the quantity of dibromohexan incorporated seems to be sufficient to obtain a gel.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
E. Rotureau, M. Leonard, E. Marie, and E. Dellacherie, Colloids Surf., A, 288, 131 (2006).
E. Rotureau, E. Marie, M. Leonard, E. Dellacherie, T. A. Camesano, and A. Durand, Colloids Surf., A, 288, 62 (2006).
C. Rouzes, M. Leonard, A. Durand, and E. Dellacherie, Colloids Surf., B, 32, 125 (2003).
C. Lemarchand, R. Gref, C. Passirani, E. Garcien, B. Petri, R. Müller, D. Constantino, and P. Couvreur, Biomaterials, 27, 108 (2006).
M. Q. Gu, X. D. Yuan, C. S. Kang, Y. H. Zhao, N. J. Tian, P. Y. Pa, and J. Sheng, Carbohydr. Polym., 67, 417 (2007).
N. Venkatesan and S. P. Vyas, Int. J. Pharm., 203, 169 (2000).
M. Leonard, M. Rastello de Boisseson, P. Hubert, F. Dalençon, and E. Dellacherie, J. Controlled Release, 98, 395 (2004).
R. Rodriguez, C. Alvarez-Lorenzo, and A. Concheiro, Eur. J. Pharm. Sci., 20, 429 (2003).
L. Noble, A. I. Gray, L. Sadiq, and I. F. Uchegbu, Int. J. Pharm., 192, 173 (1999).
K. Akiyoshi, S. Deguchi, N. Moriguchi, S. Yamaguchi, and J. Sunamoto, Macromolecules, 26, 3062 (1993).
T. Nishikawa, K. Akiyoshi, and J. Sunamoto, J. Am. Chem. Soc., 118, 6110 (1996).
K. Akiyoshi, S. Kobayashi, S. Shichibe, D. Mix, M. Bardy, S. W. Kim, and J. Sunamoto, J. Controlled Release, 54, 313 (1998).
K. Ikeda, T. Okada, S. I. Sawada, K. Akiyoshi, and K. Matsuzaki, FEBS Lett., 580, 6587 (2006).
K. Na, T. B. Lee, K. H. Park, E. K. Shin, Y. B. Lee, and H. K. Choi, Eur. J. Pharm. Sci., 18, 165 (2003).
S. Vinogradov, E. Batrakova, and A. Kabanov, Colloids Surf., B, 16, 291 (1999).
S. Vinogradov, E. V. Batrakova, and A. Kabanov, Bioconjugate Chem., 15, 50 (2004).
S. Vinogradov, E. Kohli, and A. D. Zeman, Mol. Pharmaceutics, 2, 449 (2005).
V. Dulong, D. Le Cerf, L. Picton, and G. Muller, Colloids Surf., A, 274, 163 (2006).
T. Coviello, M. Grassi, G. Rambone, E. Santucci, M. Carafa, E. Murtas, F. M. Riccieri, and F. Alhaique, J. Controlled Release, 60, 367 (1999).
T. Coviello, M. Grassi, G. Rambone, and F. Alhaique, Biomaterials, 22, 1899 (2001).
S. Simon, J. Y. Dugast, D. Le Cerf, L. Picton, and G. Muller, Polymer, 44, 7917 (2003).
C. Duval, D. Le Cerf, L. Picton, and G. Muller, J. Chromatogr. B, 753, 115 (2000).
R. W. Eyler, T. S. Klug, and F. Siephuis, Anal. Chem., 19, 24 (1947).
S. V. Vinogradrov, T. K. Bronich, and A. V. Kabanov, Adv. Drug Delivery Rev., 54, 135 (2002).
V. Crescenzi, A. Francescangeli, A. Taglienti, D. Capitani, and L. Mannina, Biomacromolecules, 4, 1045 (2003).
A. S. Hoffman, Adv. Drug Delivery Rev., 43, 3 (2002).
S. Simon, G. Mocanu, L. Picton, D. Le Cerf, and G. Muller, e-polymers, 38, 1 (2004).
C. Creuzet, S. Kadi, M. Rinaudo, and R. Auzily-Velty, Polymer, 47, 2706 (2006).
J. Desbrières, C. Martinez, and M. Rinaudo, Int. J. Biol. Macromol., 19, 21 (1996).
E. Volpert, J. Selb, and F. Candau, Polymer, 39, 1025 (1998).
S. Biggs, J. Selb, and F. Candau, Polymer, 34, 580 (1993).
V. Crescenzi, A. Francescangeli, D. Capitani, L. Mannina, D. Renier, and D. Bellini, Carbohydr. Polym., 53, 311 (2003).
D. Capitani, A. A. De Angelis, V. Crescenzi, G. Masci, and A. L. Segre, Carbohydr. Polym., 45, 245 (2001).
S. C. Chen, Y. C. Wu, F. L. Mi, Y. H. Lin, L. C. Yu, and H. W. Sung, J. Controlled Release, 96, 285 (2004).
P. Matricardi, M. Dentini, V. Crescenzi, and S. B. Ross-Murphy, Carbohydr. Polym., 27, 215 (1995).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Legros, M., Cardinael, P., Dulong, V. et al. Metastable Amphiphilic Hydrogels Based on Crosslinked Carboxymethylpullulan. Polym J 40, 233–240 (2008). https://doi.org/10.1295/polymj.PJ2007143
Received:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1295/polymj.PJ2007143
