Abstract
The rapid development of DNA nanotechnology has enabled the precise bottom-up integration of metal nanoparticles (NPs) on a nanometer scale. The recent introduction of the DNA origami technique has facilitated even more complicated control of the positioning of not only 2 dimensional (D) but also 3D structures. The basic idea and recent distinctive examples of such metal NP arrays on DNA nanostructure are briefly reviewed.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Eustis, S. & El-Sayed, M. A. Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. Chem. Soc. Rev. 35, 209–217 (2006).
Daniel, M. C. & Astruc, D. Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem. Rev. 104, 293–346 (2004).
Rosi, N. L. & Mirkin, C. A. Nanostructures in biodiagnostics. Chem. Rev. 105, 1547–1562 (2005).
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C. & Mirkin, C. A. Gold nanoparticles for biology and medicine. Angew. Chem. Int. Ed. 49, 3280–3294 (2010).
Barrow, S. J., Funston, A. M., Gomez, D. E., Davis, T. J. & Mulvaney, P. Surface plasmon resonances in strongly coupled gold nanosphere chains from monomer to hexamer. Nano Lett. 11, 2489–3492 (2011).
Jiang, L., Wang, W., Fuchs, H. & Chi, L. One-dimensional arrangement of gold nanoparticles with tunable interparticle distance. Small 5, 2819–2822 (2009).
Tang, Z. & Kotov, N. A. One-dimensional assemblies of nanoparticles: preparation, properties, and promise. Adv. Mater. 17, 951–962 (2005).
Seeman, N. Nanomaterials based on DNA. Annu. Rev. Biochem. 79, 65–87 (2010).
Lin, C., Liu, Y. & Yan, H. Designer DNA nanoarchitectures. Biochemistry 48, 1663–1674 (2009).
Endo, M. & Sugiyama, H. Chemical approaches to DNA nanotechnology. ChemBioChem. 10, 2420–2443 (2009).
Rothemund, P. W. K. Folding DNA to create nanoscale shapes and patterns. Nature 440, 297–302 (2006).
Tørring, T., Voigt, N. V., Nangreave, J., Yan, H. & Gothelf, K. DNA origami: a quantum leap for self-assembly of complex structures. Chem. Soc. Rev. 40, 5636–5646 (2011).
Sacca, B. & Niemeyer, C. M. DNA Origami: the art of folding DNA. Angew. Chem. Int. Ed. 51, 58–66 (2012).
Kuzuya, A. & Komiyama, M. DNA origami: fold, stick, and beyond. Nanoscale 2, 310–322 (2010).
Shih, W. M. & Lin, C. Knitting complex weaves with DNA origami. Curr. Opin. Struc. Biol. 20, 276–282 (2010).
Tan, S. J., Campolongo, M. J., Luo, D. & Cheng, W. Building plasmonic nanostructures with DNA. Nat. Nanotech. 6, 268–276 (2011).
Pinto, Y. Y., Le, J. D., Seeman, N. C., Musier-Forsyth, K., Taton, T. A. & Kiehl, R. A. Sequence-encoded self-assembly of multiple-nanocomponent arrays by 2D DNA scaffolding. Nano Lett. 5, 2399–2402 (2005).
Sharma, J., Chhabra, R., Liu, Y., Ke, Y. & Yan, H. DNA-templated self-assembly of two-dimensional and periodical gold nanoparticle arrays. Angew. Chem. Int. Ed. 45, 730–735 (2006).
Lo, P. K., Karam, P., Aldaye, F. A., McLaughlin, C. K., Hamblin, G. D., Cosa, G. & Sleiman, H. F. Loading and selective release of cargo in DNA nanotube with longitudinal variation. Nat. Chem. 2, 319–328 (2010).
Mastroianni, A. J., Claridge, S. A. & Alivisatos, A. P. Pyramidal and chiral groupings of gold nanocrystals assembled using DNA scaffolds. J. Am. Chem. Soc. 131, 8455–8459 (2009).
Chen, W., Bian, A., Agarwal, A., Liu, L., Shen, H., Wang, L., Xu, C. & Kotov, N. A. Nanoparticle superstructures made by polymerase chain reaction: collective interactions of nanoparticles and a new principle for chiral materials. Nano Lett. 9, 2153–2159 (2009).
Kim, J. W., Kim, J. H. & Deaton, R. DNA-linked nanoparticle building blocks for programmable matter. Angew. Chem. Int. Ed. 50, 9185–9190 (2011).
Li, Z., Cheng, E., Huang, W., Zhang, T., Yang, Z., Liu, D. & Tang, Z. Improving the yield of mono-DNA-functionalized gold nanoparticles through dual steric hindrance. J. Am. Chem. Soc. 133, 15284–15287 (2011).
Suzuki, K., Hosokawa, K. & Maeda, M. Controlling the number and positions of oligonucleotides on gold nanoparticle surfaces. J. Am. Chem. Soc. 131, 7518–7519 (2009).
Tamaki, T., Miyoshi, N., Uehara, T. & Ohya, Y. Isolation of gold nanoparticle/oligo-DNA conjugates by the number of oligo-DNAs attached and their formation of self-assembly. Chem. Lett. 39, 1084–1085 (2010).
Ohya, Y., Miyoshi, N., Hashizume, M., Tamaki, T., Uehara, T., Shingubara, S. & Kuzuya, A. Formation of 1D and 2D gold nanoparticle arrays by divalent DNA-gold nanoparticle conjugates. Small (in press).
Rinker, S., Ke, Y., Liu, Y., Chhabra, R. & Yan, H. Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding. Nat. Nanotech. 3, 418–422 (2008).
Ke, Y., Lindsay, S., Chang, Y., Liu, Y. & Yan, H. Self-assembled water-soluble nucleic acid probe tiles for label-free RNA hybridization assays. Science 319, 180–183 (2008).
Sharma, J., Chhabra, R., Andersen, C. S., Gothelf, K. V., Yan, H. & Liu, Y. Toward reliable gold nanoparticle patterning on self-assembled DNA nanoscaffold. J. Am. Chem. Soc. 130, 7820–7821 (2008).
Pal, S., Deng, Z., Ding, B., Yan, H. & Liu, Y. DNA-origami-directed self-assembly of discrete silver-nanoparticle architectures. Angew. Chem. Int. Ed. 49, 2700–2704 (2010).
Pal, S., Varghese, R., Deng, Z., Zhao, Z., Kumar, A., Yan, H. & Liu, Y. Site-specific synthesis and in situ immobilization of fluorescent silver nanoclusters on DNA nanoscaffolds by use of the Tollens reaction. Angew. Chem. Int. Ed. 50, 4176–4179 (2011).
Pal, S., Deng, Z., Wang, H., Zou, S., Liu, Y. & Yan, H. DNA directed self-assembly of anisotropic plasmonic nanostructures. J. Am. Chem. Soc. 133, 17606–17609 (2011).
Ding, B., Deng, Z., Yan, H., Cabrini, S., Zuckermann, R. & Bokor, J. Gold nanoparticle self-similar chain structure organized by DNA origami. J. Am. Chem. Soc. 132, 3248–3249 (2010).
Kuzuya, A., Numajiri, K. & Komiyama, M. Accommodation of a single protein guest in nanometer-scale wells embedded in a ‘DNA nanotape’. Angew. Chem. Int. Ed. 47, 3400–3402 (2008).
Kuzuya, A., Kimura, M., Numajiri, K., Koshi, N., Ohnishi, T., Okada, F. & Komiyama, M. Precisely programmed and robust 2D streptavidin nanoarrays by using periodical nanometer-scale wells embedded in DNA origami assembly. ChemBioChem 10, 1811–1815 (2009).
Kuzuya, A., Koshi, N., Kimura, M., Numajiri, K., Yamazaki, T., Ohnishi, T., Okada, F. & Komiyama, M. Programmed nanopatterning of organic/inorganic nanoparticles using nanometer-scale wells embedded in a DNA origami scaffold. Small 6, 2664–2667 (2010).
Numajiri, K., Kuzuya, A. & Komiyama, M. Asymmetric secondary and tertiary streptavidin/DNA complexes selectively formed in a nanometer-scale DNA well. Bioconjugate Chem. 21, 338–344 (2010).
Numajiri, K., Kimura, M., Kuzuya, A. & Komiyama, M. Stepwise and reversible nanopatterning of proteins on a DNA origami scaffold. Chem. Commun. 46, 5127–5129 (2010).
Numajiri, K., Yamazaki, T., Kimura, M., Kuzuya, A. & Komiyama, M. Discrete and active enzyme nanoarrays on DNA origami scaffolds purified by affinity tag separation. J. Am. Chem. Soc. 132, 9937–9939 (2010).
Yurke, B., Turberfield, A. J., Mills, A. P., Simmel, F. C. & Neumann, J. L. A DNA-fuelled molecular machine made of DNA. Nature 406, 605–608 (2000).
Endo, M., Yang, Y., Emura, T., Hidaka, K. & Sugiyama, H. Programmed placement of gold nanoparticles onto a slit-type DNA origami scaffold. Chem. Commun. 47, 10743–10745 (2011).
Zhao, Z., Jacovetty, E. L., Liu, Y. & Yan, H. Encapsulation of gold nanoparticles in a DNA origami cage. Angew. Chem. Int. Ed. 50, 2041–2044 (2011).
Douglas, S. M., Dietz, H., Liedl, T., Hoegberg, B., Graf, F. & Shih, W. M. Self-assembly of DNA into nanoscale three-dimensional shapes. Nature 459, 414–418 (2009).
Shen, X., Song, C., Wang, J., Shi, D., Wang, Z., Liu, N. & Ding, B. Rolling up gold nanoparticle-dressed DNA origami into three-dimensional plasmonic chiral nanostructures. J. Am. Chem. Soc. 134, 146–149 (2012).
Gu, H., Chao, J., Xiao, S. J. & Seeman, N. C. A proximity-based programmable DNA nanoscale assembly line. Nature 465, 202–206 (2010).
Lund, K., Manzo, A. J., Dabby, N., Michelotti, N., Johnson-Buck, A., Nangreave, J., Taylor, S., Pei, R., Stojanovic, M. N., Walter, N. G., Winfree, E. & Yan, H. Molecular robots guided by prescriptive landscapes. Nature 465, 206–210 (2010).
Wickham, S. F. J., Endo, M., Katsuda, Y., Hidaka, K., Bath, J., Sugiyama, H. & Turberfield, A. J. Direct observation of stepwise movement of a synthetic molecular transporter. Nat. Nanotech. 6, 166–169 (2011).
Kuzuya, A., Sakai, Y., Yamazaki, T., Xu, Y., Komiyama, M. & Nanomechanical, DNA origami ‘single-molecule beacons’ directly imaged by atomic force microscopy. Nat. Commun. 2, 449 (2011).
Acknowledgements
The authors’ works introduced in this review are partially funded by a Grant-in-Aid for Challenging Exploratory Research from the Japan Society for the Promotion of Science (JSPS); a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) Japan; the Kurata Memorial Hitachi Science and Technology Foundation and the Murata Science Foundation.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Kuzuya, A., Ohya, Y. DNA nanostructures as scaffolds for metal nanoparticles. Polym J 44, 452–460 (2012). https://doi.org/10.1038/pj.2012.38
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/pj.2012.38
Keywords
This article is cited by
-
Nucleic acid-based fluorescent sensor systems: a review
Polymer Journal (2022)
-
Nuclease resistance of DNA nanostructures
Nature Reviews Chemistry (2021)
-
Metal nanoarchitecture fabrication using DNA as a biotemplate
Polymer Journal (2017)
-
Technical Reviews start in Polymer Journal
Polymer Journal (2016)
-
Encapsulation of a gold nanoparticle in a DNA origami container
Polymer Journal (2015)
