Abstract
Evidence was presented at these meetings last year that human leukocyte G-6-PD activity decayed at significantly greater rates in newborns than in adults. Quantitative NBT dye reduction was correspondingly low provided collection, incubation and measurement times were carefully controlled. The present studies reflect longitudinal maturation of these functions as shown in the table.
These results show a fall in both G-6-PD activity and NBT dye reduction during early months of life followed by a continuous increase with maturation. In contrast, levels of 6-PGD activity remain constant. Lability of G-6-PD and diminished NBT dye reduction are also present in chronic granulomatous disease, an immune deficiency disorder associated with defective bactericidal activity of leukocytes [BELLANTI et al., Pediat. Res. 1970]. These findings offer an explanation for the increase in resistance known to occur with age.
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Bellanti, J., Cantz, B., Yang, M. et al. Leukocyte Maturation: G-6-PD Activity and NBT Dye Reduction. Pediatr Res 4, 462 (1970). https://doi.org/10.1203/00006450-197009000-00111
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DOI: https://doi.org/10.1203/00006450-197009000-00111
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