Abstract
Extract: The relations of total zinc, manganese, nucleic acids, and protein in the livers of control, hypophysectomized, and calorie-restricted rats were eveluated by regression analysis and analysis of covariance (tables I through V).
The most striking findings were the demonstration of a continuous relation between RNA and zinc in the livers of the control rats and of experimental groups (fig. 2), and an absolute increase in the content of manganese in the livers of the calorie-restricted animals (fig. 3).
It is suggested that zinc is important for the maintenance of ribonucleic acid synthesis and sub sequent protein synthesis in mammalian tissues.
Speculation: In bilogical tissues, ribonucleic acid is a necessary precursor for protein synthesis; possibly zinc, acting as a confactor, is of equal importance.
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Holt, N., Mellits, E. & Cheek, D. Comparisons Between Nucleic Acids, Protein, Zinc, and Manganese in Rat Liver: A Relation Between Zinc and Ribonucleic Acid. Pediatr Res 4, 157–164 (1970). https://doi.org/10.1203/00006450-197003000-00006
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DOI: https://doi.org/10.1203/00006450-197003000-00006
