Abstract
The purpose of this study is to know if saliva and serum of cystic fibrosis have a general activity on membrane transports and if there is a common abnormal factor in blook and saliva. The method measures the variations of rat intestinal uptake on alanine which is in relation with Na movements. Two groups of 10 children with cystic fibrosis were compared with a pool of normal children. The fresh saliva of the first group was in contract for 10 min with an everted ring of normal rat jejunum. The ring was then incubated 60 min in K.R.B. with 0.8 min|liter 11C-alanine. The fresh serum of the second group was placed in the incubation medium for 60 min with 11C-alanine. The saliva of cystic fibrosis inhibits alanine uptake from 6 to 50% compared with normal pool saliva. These results seem constant with a dilution from ¼ to 1/20. No significant diffrence could be obtained with fresh or congealed serum with a dilution from ¼ to 1/20. Saliva (and, perhaps, other exocrine secretions) of cystic fibrosis has a general effect on cellular uptake (probably on Na uptake). But it seems that this factor is different from the abnormal factor of the serum of custic librosis.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Desjeux, J., Morin, C. 10. Effect of saliva and serum of cystic fibrosis on alanine in vitro intestinal transport. Pediatr Res 5, 84–85 (1971). https://doi.org/10.1203/00006450-197102000-00015
Issue date:
DOI: https://doi.org/10.1203/00006450-197102000-00015
