A controlled study of intravenous fibrin hydrolysate supplement in prematures < 1.3 kg

Abstract

We have compared the effect of early supplemental intravenous 3.5% fibrin hydrolysate plus 10% dextrose to 10% dextrose alone on the mortality, morbidity, weight gain and biochemical changes in 2 equal groups of 15 low birth weight infants of appropriate gestation. The initial alimentation was intravenous with gradual repalcement by oral formula over the first 2 weeks of life. Total fluid intake of 200 ml/kg/day was maintained. Total caloric intake and urinary output did not differ between groups. The amino acid infants received twice the amount of protein (g/kg/day) as the controls. Mortality did not differ between groups when infants were assessed by body weight. In the survivors apnoca was significantly less frequent in those receiving amino acid and regain of birth weight more rapid. Total protein and BUN were higher in those on amino acid reflecting increased N₂ intake, and serum PO₄ lower. Serum electrolytes, sugar, osmolality, HCO₃ did not differ. Fatal cases in the amino acid group, many <1.0 kg, exhibited an excessive rise in BUN, and high plasma osmolality within 3 days of infusion.

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