Abstract
42 puppies (age 14 to 26 days) have been studied in standardized haemorrhagic shock.
During the normovolaemic phase 8 puppies were treated with 1 mg aldosterone/kg/h, 6 puppies with 2 mg/kg/h, over a period of 4 hours. 28 untreated pupies served as controls.
Blood pressure, heart rate, rectal temperature, pH and plasma potassium come back to normal in the aldosterone treated animals. These effects are more evident when 2 mg aldosterone/kg/h are given.
Urine production is substantially improved. Average survival time is 1.6 and 6 times longer in animals treated with 1 and 2 mg aldosterone/kg/h, respectively, than in controls.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hollmann, G., Koczorek, K., Angerpointner, T. et al. A NEW APPROACH IN SHOCK THERAPY DURING EARLY LIFE: Experimental study. Pediatr Res 8, 142 (1974). https://doi.org/10.1203/00006450-197402000-00098
Issue date:
DOI: https://doi.org/10.1203/00006450-197402000-00098
