Abstract
Dibutyryl cyclic AMP in the presence of theophylline was found to induce tyrosine aminotransferase and phenylalanine hydroxylase activities in human fetal liver in organ culture. These effects were completely inhibited by simultaneous incubation with cycloheximide. Corticosteroids were also found to increase tyrosine aminotransferase activity. These results demostrate the competence of mid-term human fetal liver to respond to certain drugs by increasing specific enzyme activity. The potential importance of these findings will be discussed in relation to clinical neonatal problems caused by immature liver function.
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Raiha, N., Schwartz, A. DEVELOPMENT OF ENZYMES AND DRUG ACTIONS: ENZYME INDUCTION IN HUMAN FETAL LIVER IN ORGAN CULTURE. Pediatr Res 8, 132 (1974). https://doi.org/10.1203/00006450-197402000-00034
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DOI: https://doi.org/10.1203/00006450-197402000-00034
