Abstract
In the adult rat liver the enzyme-glutamyl-transpeptidase (GGTP) is bearly measurable, whereas the newborn rat exhibits about 20 times more activity. A derepression of this enzyme has been reported in rat hepatomas. GGTP was measured in adult rats after an end to side portacaval shunt (PCS). Enzyme activity was almost unmeasurable in the control group whereas already ten days after PCS a tenfold increase was observed. The hypothesis is advanced that this increase after PCS may be regarded as a reacquirement of an embryonal biochemical feature, which predominates in the fetal liver and is repressed in the adult life, but may be activated following PCS.
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Colombo, J., Bircher, J. ACQUISITION OF AN EMBRYONAL BIOCHEMICAL FEATURE IN THE RAT LIVER AFTER PORTACAVAL SHUNT. Pediatr Res 8, 132 (1974). https://doi.org/10.1203/00006450-197402000-00036
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DOI: https://doi.org/10.1203/00006450-197402000-00036
