Abstract
Bone Mineral Content (BMC) was determined by the photon absorption method of Cameron and Sorenson in 58 black children (33 females and 25 males) with confirmed sickle cell anemia (SS). Bone scans were performed through the mid-radius (cortical bone) using 125-iodine as a monochromatic source of photons. Data is expressed both as GM/cm scanned or as the ratio of BMC to bone width (BMC/BW). The values obtained in these patients were compared to values in normal black and white children. BMC in normal black and white children showed what appeared to be a linear increase with age. In accordance with the data of Trotter, et al, we found that radius BMC is higher in black than in white at all ages, although accuracy and precision are less below the age of two. 64%. of males and 39% of females with sickle cell disease have less BMC than normal black children of the same age (less than 95% confidence limits). The ratio BMC/BW as related to age follows the normal pattern indicating similar reduction in BMC and BW in affected children. The factors contributing to the sex difference as regards the mineralization are not clear. Severity of anemia and transfusion need are considered as possible factors determining the extent of mineral loss.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Epps, C., Shapiro, J., Moore, W. et al. IN VIVO BONE MINERAL CONTENT IN SICKLE CELL ANEMIA. Pediatr Res 8, 400 (1974). https://doi.org/10.1203/00006450-197404000-00358
Issue date:
DOI: https://doi.org/10.1203/00006450-197404000-00358
