Abstract
Isolation of E6 from the nasopharynx (N-P) of a 5 month old unimmunized child (patient #1) hospitalized with clinical pertussis was accompanied by a fourfold rise in neutralizing (N) antibody to this virus. (Table) The illness occurred in Aug. and Sept., produced significant symptoms for 4 weeks, and was accompanied by an absolute lymphocytosis. B. pertussis was not isolated from her N-P and no pertussis agglutinins were demonstrated.
13 of 15 family members ranging in age from 1-48 yrs reported clinical illness with prominent respiratory symptoms during the 2 months preceding hospitalization of the index case. A 4 yr old immunized cousin (patient 2) with paroxysmal cough and cyanosis also had E6 isolated from her N-P. 8 of 9 family members demonstrated serological evidence of infection with E6 but not with B. pertussis. Isolation of E6 from 2 patients and antibody liters in 10 persons associate E6 with the clinical illness in this family.
Table. Virus isolation and N antibody in 2 patients
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Wilfert, C., Idriss, Z., Fineman, R. et al. PERTUSSIS SYNDROME AND ECHOVIRUS 6(E6) INFECTION IN A FAMILY. Pediatr Res 8, 430 (1974). https://doi.org/10.1203/00006450-197404000-00540
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DOI: https://doi.org/10.1203/00006450-197404000-00540
