Abstract
The regulation of immunoreactive parathyroid hormone (IPTH) levels has been examined in three groups of children. I. In 5 children with renal insufficiency, 4 had renal osteodystrophy. Calcium infusions of 4 mg/kg/hour for 4 hours reduced IPTH to less than 40% of the elevated baseline levels. Following glucagon administration, which lowered serum calcium in 4 of 5 children, IPTH levels in 3 increased transiently by 20%. These changes indicated that these children had suppressible parathyroid function (non-autonomous). II. In 4 children being hemodialyzed against a bath with Ca++ concentration ranging from 7-8 mg/dl,the (Ca++) of the venous line progressively rose. It also always exceeded that of the arterial line, indicating net calcium absorption by the body. IPTH levels fell as serum(Ca++) increased. These changes indicate that the use of a high(Ca++) in the dialysis bath is useful in suppressing parathyroid hyperactivity. III. Changes in (Ca++), (PO−4) and IPTH were determined following 5 episodes in 4 children of acute transplant rejection being treated by 15 mg/kg of IV prednisolone.(Ca++) fell in all 5. Changes in IPTH levels were not consistent and failed to parallel changes in (Ca++). These changes suggest that high doses of steroids may acutely affect serum (Ca++), independently of their effect on the parathyroid glands.
Supported by NIH grants RR-5624, RR-75 and HD-04840.
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Gruskin, A., Root, A., Duckett, G. et al. PARATHYROID HORMONE REGULATION IN CHILDREN WITH CHRONIC RENAL DISEASE. Pediatr Res 8, 455 (1974). https://doi.org/10.1203/00006450-197404000-00692
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DOI: https://doi.org/10.1203/00006450-197404000-00692
