Abstract
In the adult, renal autoregulation may be mediated by the renin-angiotensin system(RAS). Autoregulation has not been fully investigated in the puppy. Nine, 4-5wks. old puppies were studied. Renal blood flow(RBF)was measured by electromagnetic flow meter. Sar1ala8angiotensin II(anti II)an antagonist of angioten sin II(AII)was administered into the renal artery(4ug/min)and subsequently intravenously(IV)(4ug/min) In both instances RBF(1.6±0.3ml/gm/min)was unchanged by anti II and mean arterial pressure(MAP)remained constant (78±4mmHg). In 6 puppies, during intrarenal infusion of anti II, All given IV raised MAP to 100mmHg. RBF increased promptly from 1.6±0.3 to 2.0±0.6ml/gm/min but returned to control levels within 40sec. in spite of persistent MAP elevation. In 3 other puppies reduction of renal perfusion pressure by aortic constriction to 50mmHg did not cause a fall in RBF.
This model provides a useful new means of defining autoregulation. In these puppies, renal autoregulation, RBF and arterial pressure are not regulated by the RAS.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jose, P., Slotkoff, L., Montgomery, S. et al. AUTOREGULATION IN THE IMMATURE KIDNEY. Pediatr Res 8, 456 (1974). https://doi.org/10.1203/00006450-197404000-00695
Issue date:
DOI: https://doi.org/10.1203/00006450-197404000-00695
