Abstract
The purpose of this report is to describe a syndrome of delayed respiratory distress occurring in premature infants, usually under 1250 gms. at birth. Unlike hyaline membrane disease (HMD), this syndrome occurs after 5-10 days of life in a previously healthy infant; unlike HMD it persists for 2-4 weeks. Chronic pulmonary insufficiency of prematurity (CPIP) carries a 10-20% mortality. The infants are frequently apneic and require supplemental oxygen, but lack the characteristic radiologic findings of HMD, bronchopulmonary dysplasia, Wilson-Mikity syndrome, or oxygen toxicity. Compared to healthy infants under 1250 gm. at birth (nl) infants with CPIP demonstrate the following abnormalities:
Recovery is usually complete in 60 days. An awareness of CPIP can eliminate a false sense of security, often communicated to anxious parents, during the 5-10 day period before the onset of CPIP. The physiologic similarity between CPIP and HMD suggests lack of surfactant as the etiology of CPIP.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Auld, P., Krauss, A. & Klain, D. CHRONIC PULMONARY INSUFFICIENCY OF PREMATURITY (CPIP). Pediatr Res 8, 464 (1974). https://doi.org/10.1203/00006450-197404000-00744
Issue date:
DOI: https://doi.org/10.1203/00006450-197404000-00744
