Abstract
76 children (age 2-l6) with bronchial asthma received pyridoxlne (200 mg) daily or placebo in a double-blind study. Each day their parents completed data sheets assessing their symptoms and other medications. Each month they were examined by their allergist and provided vith new sheets and modication. Duration of the study vas 5 months. There were no significant differences in the 2 groups at the outset, but by the second month the pyridoxine group had significantly (p < 0.02) less asthma attacks, and less bronchodilator medicine vas being used. Significant differences in wheezing, tightness in chest, breathing difficulty and cough medicine were also seen. We had previously reported (SPR, 1972) significant abnormality in excretion of xanthurenic and kynurenic acid before and after oral tryptophane loading which returned toward normal with oral pyridoxine therapy. These and other studies suggest that asthmatic children have a relative Increase in serotonin and decrease in epinephrine production which are at least partially reversible with pyridoxine therapy.
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Collipp, P., Goldzier, S., Weiss, N. et al. PYRIDOXINE TREATMENT OF BRONCHIAL ASTHMA. Pediatr Res 8, 465 (1974). https://doi.org/10.1203/00006450-197404000-00753
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DOI: https://doi.org/10.1203/00006450-197404000-00753
