Abstract
A combination of insulin hypoglycemia with administration of the recently synthesised releasing hormones TRH and LH-RH allows almost complete evaluation of the anterior pituitary function in one single test. The combined test was performed in over 60 children with suspected hypothalamo-pituitary disorders. Insulin (0,1 U/kg) was injected intravenously followed by TRH (200 ug) followed by LH-RH (100 ug). Growtn hormone, ACTH, LH, FSH, TSH and cortisol were measured by radibimmunoassay and blood sugar by an enzymatic technique. The assays were shown to be specific and there were no cross reactions between the different hormones assayed. The normal response to insulin hypoglycemia is not altered by simultaneous injection of the releasing hormones. Similarly the TSH-response to TRH alone does not differ from that observed during a combined test. The combined test has proved to be useful for the differential diagnosis of short stature in children and various disorders of suspected pituitary hypothalamic origin. The diagnosis of an isolated or combined hormone deficiency can thus be made on the basis of a single test.
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Girard, J., Staub, J., Baumann, J. et al. ASSESSMENT OF HYPOTHALAMO-ANTERIOR PITUITARY SECRETING CAPACITY IN CHILDREN ON THE BASIS OF A SINGLE TEST. Pediatr Res 9, 686 (1975). https://doi.org/10.1203/00006450-197508000-00116
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DOI: https://doi.org/10.1203/00006450-197508000-00116
