Abstract
A controlled trial of elective intervention with CIP was performed in infants weighing > 1000 g whose PaO2 fell < 60 mmHg with an FIO2 > 0.95. 11 of 12 treated and 10 of 12 control infants survived. 7 treated and 6 controls needed mechanical ventilation /MV/.CIP caused a significant increase in PaO2 and the treated infants breathed high concentrations of oxygen for a shorter period than the controls. During the trial period /31 months/ 107 other infants with severe HMD were admitted who did not meet the criteria for entry to the trial 37 survivied after breathing an FIO2 > 0.60 without CIP or MV. The other 70 needed MV, usually because they were already being ventilated on arrival from other hospitals. The neonatal survival rate for infants born at U.C.H. during the study period was 88% /50/57/ and for referred infants, 69 % /51/74/. The maximum overall increase in survival rate that might have been achieved by very early intervention with CIP was 5 % /from 77% to 83%/.
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Durbin, G., Hunter, N., McIntosh, N. et al. CONTROLLED TRIAL OF CONTINUOUS INFLATING PRESSURE /CIP/ FOR HYALINE MEMBRANE DISEASE /HMD/. Pediatr Res 9, 858 (1975). https://doi.org/10.1203/00006450-197511000-00038
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DOI: https://doi.org/10.1203/00006450-197511000-00038
