Abstract
Elevated total serum creatine phosphokinase /CPK/ activity / 200 U/l/ was found during the first week of life /peak between 24–48 hrs/ in 32 out of 76 newborn infants, having had birth asphyxia. Of the 32 neonates with elevated total serum CPK 27 survived and in 26 the EEG, neuromotor- and mental development were followed at regular intervals up to the age of one year. By the last follow-up examination 13 infants revealed signs of neurological and/or mental abnormality. Isoenzyme separation on DEAE Sephadex A 50, according to Dubo et al., was performed in 23 cases showing elevated total CPK activity during the neonatal period. The brain specific isoenzyme fraction increased above the normal upper limit of 45 U/1 in 13 infants /range 45.8 U/1–449.6 U/1/: 9 showed neurological and mental defects at the age of 1 year. It has been concluded that the coicidence of birth asphyxia with an activity of more than 200 U/1 in total serum CPK and the increase of the brain specific isoenzyme fraction by 15 per cent or more of the total CPK means a bad prognosis regarding neuromotor and mental development.
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Menzel, K. DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF SERUM TOTAL CREATINE PHOSPHOKINASE AND BRAIN SPECIFIC ISOENZYME ACTIVITY IN ASPHYCTIC NEWBORN INFANTS. Pediatr Res 9, 860 (1975). https://doi.org/10.1203/00006450-197511000-00052
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DOI: https://doi.org/10.1203/00006450-197511000-00052
