Abstract
It was earlier found that an extreme degree of hyperuricaemia can be detected in the blood in severe clinical conditions accompanied by hypoxia. In our present examinations we showed that the poorly bloodsoluble uric acid is precipitated in the form of microcrystals, and phagocytized uric acid crystals in the leukocytes can be detected in the blood of clinical cases of acute metabolic disturbance and hypoxaemia in native preparations with a polarizing microscope. Uricase paralysis in rats /specific enzymatic inhibition with oxonic acid/ enhances the shock sensitivity; the hyperuricaemia induces urate nephropathy of the uric acid in the kidneys, and phagocytized uric acid microcrystals can be observed in the leukocytes. Basides oxonic acid-induced uricase paralysis, xanthine oxidase paralysis with allopurinol /Milurit/ makes rats appreciably tolerant to shock. These results show the particular importance the disturbance of uric acid metabolism in acute metabolic diseases and shock states.
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Boda, D., Virág, I. & Zsilinszky, N. CLINICAL AND EXPERIMENTAL EXAMINATIONS RELATING TO THE PATHOLOGICAL SIGNIFICANCE OF HYPERURICAEMIA IN ACUTE METABOLIC DISTURBANCES. Pediatr Res 9, 862 (1975). https://doi.org/10.1203/00006450-197511000-00062
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DOI: https://doi.org/10.1203/00006450-197511000-00062
