Abstract
One hour blood xylose screening test is often used as a measure of monosaccharide absorption in intestinal malabsorption. Glucose transport is known to be coupled with Na transport; therefore the effect of xylose and glucose on active Na absorption was determined by measurement of short circuit current /Isc/ on adjacent pieces of rabbit intestine /J.Gen.Physiol. 47 : 567.1964/. Glucose /1 to 40 mM/ stimulated Isc. The maximum increase, Δ Isc, was 0.80 ueq/hr cm2 in ileum and 0.56 ueq/hr cm2 in jejunum. In contrast, xylose /10 to 40 mM/ did not significantly increase Isc /Δ Isc=0/. The addition of glucose /1 to 40 mM/ to the intestine previously exposed to 40 mM xylose stimulated Isc. These results indicate that xylose does not stimulate active Na absorption. They further suggest that the decrease of xylose absorption in some malabsorptions may not be directly related to a decrease of active transport on monosaccharides.
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Bertrand, N., Chevrot, M., Robert, J. et al. EFFECT OF D-XYLOSE ON ACTIVE SODIUM TRANSPORT IN ISOLATED RABBIT INTESTINE. Pediatr Res 9, 867 (1975). https://doi.org/10.1203/00006450-197511000-00089
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DOI: https://doi.org/10.1203/00006450-197511000-00089
