Abstract
Neonatal hypocalcemia is common in P.I. It is not clear whether it results from transient hypoparathyroidism on unresponsiveness to parathyroid hormone /PTH/. Serum levels of calcium /Ca/, phosphorus /P/, magnesium /Mg/ and immunoreaktive PTH were determined in 55 P.I.-mean geatational age /GA/: 34,5 weeks; mean weight: 1,820kg-during the first 48h of life /times :0–2h; 10–14h; 22–26h; 34–38h; 44–48h/. Mean Ca decreased from 8,74+0,92/SD/ at time 0–2 to 7,80±0,93 mg/100ml at time 22–26 and then remained stable. There was no significant change in mean P and Mg. Detectable values of PTH were found in all but 2 infants at time 0–2 with mean value of 50±38 ulEq/ml /normal range for children an adults: < 50μlEq/ml with 90 % being detectable/. Then PTH levels rised steadily reaching the high mean value of 202±105 ulEq/ml at time 44–48. There was no correlation between PTH levels and G.A. at any time and several infants with very low presented with elevated PTH levels at time 0–2 which increased further later. Conclusion: Normal parathyroid responsiveness is present at birth in P.I. Therefore in P.I. neonatal hypocalcemia is not the result of transient hypoparathyroidism; other aspects of its pathogenesis will be discussed.
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David, L., Salle, B., Frederich, A. et al. PARATHYROID FUNCTION IN PREMATURE INFANTS /P.I./ OF VERY LOW BIRTH WEIGHT. Pediatr Res 9, 869 (1975). https://doi.org/10.1203/00006450-197511000-00104
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DOI: https://doi.org/10.1203/00006450-197511000-00104
