Abstract
12 homozygote patients and 32 heterozygous-gene-carriers from families with cystic fibrosis /CF/ were HLA-typed for 29 HLA-antigens. The HLA-B18 proved to be more frequent in the groups of homo- and heterozygotea 50 and 31 per cent respectively compared with 14 per cent in a control group of 130 healthy blood donors. Serum and salivary amylase activity were investigated with the using of Phadebas-amylase method. The average of total amylase activity in serum was 269 U/l±113, 7, in the CF homozygotes'group, in the heterozygotes' group was similar as in the healthy persons /210.7 U/l±86/. The CF homozygotes' salivary amylase activity was more, inci-eased* /148.7 U/l±65.1/ than in the heterozygotes' group /118.2±67.0/ and in the control ones /97.7±34.9/ The salivary amylase activity was moderately elevated in the cases of CF heterozygotes without the change of the serum total amylase activity. The amylase isoenzymes were identificated with flat-bed polyacrylamide gel-electrophoresis. Significant differences have been found in the distribution of amylase isoenzymes too.
* Change statist significant.
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László, A., Imre-Kaiser, G., Takács, O. et al. 71: HLA antigens, serum and salivary amylase activity and serum amylase isoenzymes in homozygotes and heterozygous-gene-carriers of cystic fibrosis. Pediatr Res 10, 882 (1976). https://doi.org/10.1203/00006450-197610000-00065
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DOI: https://doi.org/10.1203/00006450-197610000-00065
