95: Gonadal secretory responses to hCG in prepubertal and pubertal girls

Abstract

The ovarian responsiveness to hCG was studied in 7 girls at pubertal stage I, 7 girls at pubertal stage II and 8 subjects with complete Turner syndrome aged 15 to 20. hCG was injected IM, 3 × 1500 IU every other day after informed consent of parents. Plasma testosterone (T), androstenedione (A), progesterone (P), 17-hydroxyprogesterone (17-OHP), estradiol (E2) and cortisol (F) were measured before and after hCG by radioimmunoassays with chromatographic step. In Turner subjects the ranges of basal values were: T: 0.13-0.33 ng/ml, A: 0.27 - 1.44 ng/ml, P: Non Detectable(ND) - 0.26 ng/ml, 17-OHP: 0.27 - 1.48 ng/ml. There was no significant increase after hCG. In group I, the ranges of basal values were: T: 0.06 - 0.17 ng/ml, A: 0.08 - 0.41 ng/ml, P: ND - 0.38 ng/ml, 17-OHP: 0.15 - 2.60 ng/ml, E2: ND - 25 pg/ml, F: 45 - 120 ng/ml. Except for F, there were significant increases after hCG (p < 0.025) The ranges of increments were: T: 0.01 - 0.16 ng/ml, A: 0.08 -0.48 ng/ml, P: 0 - 1.62 ng/ml, 17-OHP: 0 - 1,61, E2: 0 - 18 pg/ml, F: −35 - +75 ng/ml. In group II, the ranges of basal values were: T: 0.05 - 0.19 ng/ml, A: 0.10 - 0.62 ng/ml, P: ND - 0.20 ng/ml, 17-OHP: 0.14 - 1.35 ng/ml, E2: 4-30 pg/ml and F: 45 - 129 ng/ml. Again there were significant increases (p < 0.025), except for F. The ranges of increments were: T: 0.09 - 0.33 ng/ml, A: 0.14 -1.84 ng/ml, P: 0 - 0.15 ng/ml, 17-OHP: −0.85 - 2.04 ng/ml, E2: 8 - 16 pg/ml, F: −69 - +83 ng/ml. These data give evidence that prepubertal ovary, like prepubertal testis, is easily responsive to hCG.

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