Abstract
Reports by others suggest that estrogen (E) administration blunts the usual metabolic response to growth hormone (GH). We gave GH (5 mg/day × 3), both with and without E (premarin 2.5 mg or ethinyl estradiol .04 mg × 3), to 2 pre-adolescent patients with GH deficiency and diabetes insipidus and to 3 patients with Turner's syndrome. All were fed a constant diet on the metabolic ward and E treatment was omitted for 1 month prior to the test. This research was approved by our Human Experimentation Committee. As judged by urinary excretion of Ca, Mg, P, N, No, K, and OH-prolrne concomitant E administration did not consistently produce a response different from that observed from GH alone. In none of the patients was the hypercalcuria accompanied by a change in serum PTH levels.
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Bruining, G., Forbes, G., Bryson, M. et al. 100: Effect of estrogen on metabolic response to growth hormone. Pediatr Res 10, 887 (1976). https://doi.org/10.1203/00006450-197610000-00091
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DOI: https://doi.org/10.1203/00006450-197610000-00091
