124: Reference values of plasma amino acid concentrations during parenreral nutrition in premature newborns and infants

Abstract

Complete parenteral nutrition using commercial solutions of crystalline amino acids may cause extreme amino acid imbalance, as we have published previously. In order to obtain reference values which can be used for estimating the proportion of these imbalances we studied the plasma amino acid concentrations by ion exchange chromatography in 1. the venous and arterial cord blood of 35 term newborns born by cesarean sectio without preceding labor, and 2. the peripheral venous blood of 40 term newborns, 3-20 days of age, who were exclusively breast-fed. Results (median/u moles/1) 1. cord vein/cord artery: Tau 112/1M, Urea 2700/3000, OH-Pro 21/20, Thr 208/199, Ser 113/103., Asn 40/37, Gin 386/434, Glu 55/62; Pro 130/129, Cit 10.4/9.3, Gly 193/178, Ala 434/283,α-NH₂adip.a. 4.8/4.9, α-NH₂but.a. 17.2/17.3, Cys 28/36, Val 176/149, Cystathionine 1.2/2.0, Met 26.7/23.6, Ile 50/42, Leu 87/73, Tyr 51/45, Phe 59/51, Orn 62/57, Lys 297/263, 1-Met-His 3.7/5.7, His 96/82, 3-Met-His 3.0/4.4 Arg 63/53, Try 47/U3. 2. peripheral vein: Tau 50, Urea 2300, OH-Pro 40, Thr 104, Ser 109, Asn 53, Gln 610, Glu 63, Pro 212, Cit 12.6, Gly 183, Ala 253, α-NH₂adip.a. 4.2, α-NH₂but.a. 13.7, Cys 52, Val 153, Cystathionine 1.0, Met 20, Ile49, Leu 104, Tyr 72, Phe 41, Orn 64, Lys 148, His 66, 3-Methyl-His 3.0, Arg 47, Try 44. During parenteral nutrition we propose to follow the reference values of cord blood in premature infants. In term newborns the values of breast-fed infants should serve as guidelines. Supported by DFG-SFB 87/D5.

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