Abstract
Fourteen children with hGH deficiency (10 with isolated and 4 with multiple hormone deficiency) underwent an OGTT followed by i. v. glucagon at 180'. Seventeen of such children underwent in addition a single i.v. glucagon test. Four children were retested during hGH therapy (6mg/week) of at least 6 months. Comparing the results to those obtained in a control group of 14 children with normal hGH we found that children lacking hGH had: a) lower basal glucose values and a lower glucose response in the single glucagon test; b) a markedly lower insulin response to glucagon in the combined and single glucagon test; c) hGH treatment raised the insulin response to i.v. glucagon. We conclude that this study a) provides further evidence for the effect of hGH on the releasable pool of insulin from the beta-cells; b) proves the augmentory effect of glucose preloading on the insulin release by i.v. glucagon, without relation to the concomitant glucose concentration; c) indicates that this effect is markedly decreased by longstanding hGH deficiency and d) is restored by hGH therapy.
‡ Established Investigator Chief Scientist's Bureau, Ministry of Health.
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Mimouni, M., Pertzelan, A., Josefsberg, Z. et al. 171: Effect of hGH lack on the insulin response to glucagon. Pediatr Res 10, 898 (1976). https://doi.org/10.1203/00006450-197610000-00162
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DOI: https://doi.org/10.1203/00006450-197610000-00162
