Abstract
We caused in rabbits an acidosis by infusion of NH4Cl solution. Following we infused NaHCO3 solution, THAM solution pH 10.2 or THAM acetic acid solution pH 8.6. In correcting the metabolic acidosis the buffers had an equal efficacy. The correction of pH and base excess in erythrocytes was more alowly by use of NaHCO3 than by use of THAM solutions, Hematocrit, plasma K, Cl and phosphate decreased by infusion of buffer solutions. Na increased by use of NaHCO3, it-decreased by use of THAM solutions. Ca was not influenced. After the infusion of THAM followed by infusion of glucose solution in newborns we could see a fall of plasma electrolytes. Therefore we think that it is not sufficient to add minerals after 24 hours or later. but it is necessary to applicate minerals earlier. From the view of Na metabolism it is our opinion that we should not use NaHCO3 for the therapy of an acid osis in newborns.
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Kellner, R., Heine, W., Stolpe, HJ. et al. EFFECTS OF THAM AND SODIUM BICARBONATE ON METABOLIC ACIDOSIS AND MINERAL METABOLISM. Pediatr Res 10, 557 (1976). https://doi.org/10.1203/00006450-197605000-00018
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DOI: https://doi.org/10.1203/00006450-197605000-00018
