Abstract
Serum iron levels /SIL/ and serum copper levels /SCL/ have been paralelly studied in 57 children with acute lymphoblastic leukaemia /ALL/, SIL and SCL were investigated by atomic absorption spectrophotometry. There were found the relationships between SIL, SCL and clinical stages of ALL and number of bone marrow blast cells. The highest mean levels were obtained in untreated children /SIL 169 ug%, SCL 261 ug%/ and in the full relapses with hyperleukocytosis and/or with extramedullary localization of ALL /SIL 163. ug%, SCL 254 ug%/. SIL and SCL were lower during treatment and in the cases with isolated organ localizations of ALL. The levels became normal when full remission was achieved /SIL 88 ug%, SCL 129 ug%/. These observations suggest that SIL and especially SCL are useful in the clinical evaluation of the stages of ALL. They can be used as both prognostic and therapeutic auxiliary test in the management of patients with ALL.
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Legutko, L., Halikowski, B. IRON AND COPPER CONCENTRATIONS IN THE SERUM OF LEUKAEMIC CHILDREN. Pediatr Res 10, 558 (1976). https://doi.org/10.1203/00006450-197605000-00021
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DOI: https://doi.org/10.1203/00006450-197605000-00021
