Abstract
To delineate the natural progression of cerebral vascular accidents in SCD and to determine the resultant structural and functional defects we investigated 29 patients (27 SS, 2 SC) who sustained strokes. Subarachnoid or intra-cerebral hemorrhage and bone marrow embolism occurred in 9 patients ages 14-35 years. Cerebral infarction occurred in 20 (19 SS, 1 SC) with a modal age of onset of 5 years. We were able to evaluate 14 long term survivors who were observed for a mean period of 9.4 years following the initial stroke. 10 (71%) had 1 or more recurrences with a mean interstroke interval of 28 months. Residual functional impairment was noted in all 14. Computerized axial tomography on 9 showed areas of low density and ventricular dilatation indicating structural brain damage. These patients were not treated with a transfusion program. Their clinical course indicates that evaluation of such therapy requires long periods of observation.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Powars, D., Pegelow, C., Wilson, B. et al. STROKE SYNDROME IN SICKLE CELL DISEASE (SCD). Pediatr Res 11, 564 (1977). https://doi.org/10.1203/00006450-197704000-01167
Issue date:
DOI: https://doi.org/10.1203/00006450-197704000-01167
