Abstract
Pulmonary edema is accompanied by hyperinflation or atelectasis in a variety of neonatal respiratory diseases. We studied the effect of these disparate lung volumes on fluid accumulation in the lung in 12 anesthetized spontaneously breathing puppies. Pulmonary arterial, left atrial, plasma colloid osmotic and bilateral airway pressures were measured continuously following separate intubation of the main stem bronchi. Unilateral hyperinflation was produced by continuous positive airway pressure (CPAP) in 5 puppies and unilateral atelectasis was produced by bronchial occlusion in 7 other puppies; the contralateral lung served as control. Extravascular lung water (ELW) was determined by subtracting lung blood water from total lung water. In the presence of an intravascular gradient favoring pulmonary edema produced by saline infusion, hyperinflation enhanced and atelectasis opposed fluid accumulation (p < 0.05).
We conclude that water balance in the lung is a function of lung inflation. Because hyperinflation by CPAP enhances fluid accumulation in the lung but improves gas exchange, we also conclude that hyperinflation must enhance the sequestration of fluid in non gas exchanging areas.
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Pang, L., Rodriguez-Martjnez, F., Stalcup, S. et al. EFFECT OF HYPERINFLATION AND ATELECTASIS ON FLUID ACCUMULATION IN THE PUPPY LUNG. Pediatr Res 11, 577 (1977). https://doi.org/10.1203/00006450-197704000-01242
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DOI: https://doi.org/10.1203/00006450-197704000-01242
