Abstract
Summary: The effect of 4-pentenoate on rat liver ornithine transcarbamylase was studied. No effect was found. It is concluded that the effect of 4-pentenoic acid on ornithine transcarbamylase reported by others was probably due to technical errors. Available evidence indicates that 4-pentenoate inhibits ureagenesis by interfering with mitochondrial energy metabolism, which in turn impairs mitochondrial ornithine transport or depletes mitochondrial ATP, impairing carbamyl phosphate synthesis, or both.
Speculation: Reported kinetic abnormalities of ornithine transcarbamylase in Reye's syndrome may be due to technical error.
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Glasgow, A. Effect of 4-Pentenoate on Rat Liver Ornithine Transcarbamylase. Pediatr Res 11, 303–304 (1977). https://doi.org/10.1203/00006450-197704000-00009
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DOI: https://doi.org/10.1203/00006450-197704000-00009
