Abstract
IL, a soybean oil preparation, is used extensively in hyperalimentation. Neutral amino acid transport in human fibroblasts was studied in cells grown in IL.
Maximum inhibition (50-60% of control) occurred at 20 mg%, i.e., at concentrations much lower than “safe” therapeutic levels. Maximal inhibition was achieved after 3 hours exposure to IL. Inhibition due to IL exposure for 1 hour appeared to be reversible while reversibility became increasingly difficult with longer exposure. Although the mechanism of transport inhibition remains unknown, the possibility of altered cell membranes must be considered. These findings suggest' an interaction between amino acids and IL when administered to children in vivo.
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Revsin, B., Lebowitz, J. & Morrow, G. INTRALIPID (IL) AND AMINO ACID TRANSPORT IN HUMAN SKIN FIBROBLASTS. Pediatr Res 11, 449 (1977). https://doi.org/10.1203/00006450-197704000-00476
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DOI: https://doi.org/10.1203/00006450-197704000-00476
