Abstract
An approach to detecting genetic predisposition in infants and children to early onset coronary heart disease (CHD) in adult life is through lipid screening and lipoprotein analysis. A study of 200 children independently ascertained and 148 children ascertained through one parent having hyperlipoproteinemia has been conducted and discloses that the lipoprotein phenotypes IIa, IIb and IV are detectable in infancy and childhood. Familial data may be subjected to alternate genetic models to seek best fit: multifactorial inheritance, single gene loci for IIa, IIb and IV, bivariate analysis and multiple alleles.
Lipid and lipoprotein levels of a given individual are best interpreted in the context of family studies. Early identification of the infant or child at risk should include family history of early onset CHD with lipid screening. Those individuals or families suspected from screening procedures as being at risk should be evaluated intensively with the goal of immediate medical modification.
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Nora, J., Winkler, R. GENETIC APPROACHES TO ATHEROSCLEROSIS IN PEDIATRIC PATIENTS. HYPERLIPOPROTEINEMIAS I. Pediatr Res 11, 461 (1977). https://doi.org/10.1203/00006450-197704000-00547
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DOI: https://doi.org/10.1203/00006450-197704000-00547
