Abstract
The clinical picture of Fanconi's anemia and the T.A.R. syndrome are very similar. In order to investigate the pathophysiology of these two conditions, we have performed in vitro bone marrow culture studies on two children with Fanconi's anemia and two children with T.A.R. syndrome. The bone marrow cells were cultured for myeloid progenitor cells in agar and for erythroid progenitor cells in methylcellulose. No colonies were observed from the cultures of the two children with Fanconi's anemia. The two children with T.A.R. syndrome grew a normal number of myeloid and erythroid colonies. Our results suggest that the basic defect in Fanconi's anemia resides in the stem cell while the defect in the T.A.R. syndrome resides in the megakaryocytic progenitor cell.
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Lui, V., Ragab, A., Findley, H. et al. BONE MARROW CULTURES IN CHILDREN WITH FANCONI'S ANEMIA AND T.A.R. SYNDROME. Pediatr Res 11, 475 (1977). https://doi.org/10.1203/00006450-197704000-00633
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DOI: https://doi.org/10.1203/00006450-197704000-00633
