Abstract
Lymphoblasts from 36 children with acute lymphocytic leukemia (ALL) and 12 with lymphoblastic lymphoma (LBL) were studied by complement-dependent microcytotoxicity with 2 nonhuman primate antisera defining leukemia- and lymphoma-associated antigens. Twenty-seven patients with ALL and one with LBL had cells reacting only with anti-chronic lymphatic leukemia (CLL) antiserum (Group I). These children were usually females with pancytopenia and no localized mass; their cells were usually periodic acid-Schiff (PAS) positive and E-rosette (ER) negative. Cells from 8 boys with LBL and 1 with ALL reacted only with anti-lymphosarcoma (LS) antiserum (Group II). All but one had a mediastinal (6) or abdominal (2) mass; their hemoglobin and platelet levels at diagnosis were higher (p < 0.05) than those of Group I patients, and their cells were usually PAS negative and ER positive. Eleven patients had cells reacting with both antisera (Group III), and showed features of both Group I and II patients.
These antisera appear able to distinguish two forms of childhood lymphoblastic malignancy with differing prognosis. Patients whose lymphoblasts reacted with CLL antiserum had PAS-positive ALL and no mass or ER positivity. Those whose lymphoblasts reacted with LS antiserum had bad prognostic features: localized mass, ER positivity, and PAS negativity.
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Raney, R., Mohanakumar, T., Metzgar, R. et al. Childhood Lymphoblastic Malignancy: Subgroups Defined by Nonhuman Primate Antisera. Pediatr Res 11, 479 (1977). https://doi.org/10.1203/00006450-197704000-00654
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DOI: https://doi.org/10.1203/00006450-197704000-00654
