Abstract
Autotransplanted splenic tissue has been shown to regenerate into implants microscopically indistinguishable from normal spleen in a variety of experimental animals. Little is known, however, about the immunologic function of such implants. The spleen is essential for the formation of antibody in response to small doses of intravenously administered particulate antigen. Response to intravenous challenge with sheep erythrocytes was determined in 12 Sprague-Dawley rats 5 months following auto-transplantation of splenic tissue into subcutaneous tissue, peritoneal cavity, or a surgically-created omental pouch. There was a marked rise in heterophile antibody titer following intravenous challenge in 10 control animals and no rise in 9 of 10 asplenic animals. Heterophile antibody titers increased in all of the animals with transplants. In addition, autotransplanted splenic tissue was able to take up intravenously injected 993Tc sulfur colloid. Thus autotransplanted splenic tissue is capable of clearing intravenously administered particulate material from the circulation and is able to have an immunologic response to intravenous antigenic challenge similar to that of the normal, intact spleen.
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Schwartz, A., Dadash-Zadeh, M., Goldstein, I. et al. AHTIBODY RESPONSE TO INTRAVENOUS IMMUNIZATION FOLLOWING SFLENIC TISSUE AUTOTRANSPLANTATION IN SPRAGUE-DAWLEY RATS. Pediatr Res 11, 494 (1977). https://doi.org/10.1203/00006450-197704000-00743
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DOI: https://doi.org/10.1203/00006450-197704000-00743
