Abstract
Two lots of bivalent groups A and C meningococcal polysaccharides were evaluated in children 2-10 years old. Molecular weights of both the A and C polysaccharides were 100,000-300,000 in Lot S and >2,000,000 in Lot X. 68 children received a single dose of vaccine (34 Lot S, 34 Lot X) and 45 received 2 doses of vaccine 2 months apart (27 Lot S and 18 Lot X). Antibody responses were assessed by indirect immuno-fluorescence (FA) and by bactericidal activity (BA). Preimmunization FA titers of anti-A and anti-C were 5.9 and 6.7. One month post-primary, anti-A FA titers were 33.5 with Lot S and 134.1 with Lot X (p< .05); BA titers were 15 and 388 (p< .01). Significant anamnestic responses to A polysaccharide were not observed after either Lot S or Lot X. Anti-C FA titers one month post-primary were 32.0 after Lot S and 121.4 after Lot X (p< .05); BA titers were 45 and 697. Neither enhancement nor suppression of anti-C responses were seen after the second dose of vaccine with either lot. Protection of infants with vaccines similar in size to Lot S has been achieved against group A, but not group C meningococcal disease. The immunogenicity of large molecular weight vaccines similar to Lot X In infants is currently under investigation.
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Gold, R., Lepow, M., Goldschneider, I. et al. IMMUNOGENICITY OF GROUPS A AND C MENINGOCOCCAL POLYSACCHARIDES OF DIFFERING MOLECULAR WEIGHTS. Pediatr Res 11, 500 (1977). https://doi.org/10.1203/00006450-197704000-00781
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DOI: https://doi.org/10.1203/00006450-197704000-00781
