Abstract
In our own control group of 58 healthy children the urinary calcium excretion (mg/kg bodyweight/24hr) was for 56 children 2.4±1.4 (S.D.) and for 4 children more than 2 S.D. above the mean. In 15 out of the 47 diabetic children who were all receiving insulin therapy, the urinary excretion of calcium was 2 S.D. above the mean of the control group. The urinary calcium excretion (mg/kg/24hr) correlated with the glucosuria: 2.1 + 0.9 urinary glucose (g/kg/24 hr); n=32, r=0.470, p less than 0.01. On the basis of this correlation the hypercalciuria in 10 of the 15 hypercalciuric children could not be attributed to glucosuria. 9 out of the 10 hypercalciuric children, where the hypercalciuria could not be attributed to glucosuria, showed on follow-up a persistent hypercalciuria. In these hypercalciuric children the tubular reabsorption of phosphate and the TmP/GFR were not different from the other diabetic children, but after a calcium load the TmP/GFR was raised significantly in the hypercalciuric group only. The urinary cAMP/creatinine ratio in the hypercalciuric children during a 2 hour fast was below that of healthy children. Plasma PTH was elevated in 3 of 32 diabetic children. Children with diabetes mellitus have an unexplained high frequency of hypercalciuria.
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Drayer, N., Van Dammee-Lombaerts, R., Rouwe, C. et al. Hypercalciuria in children with diabetes mellitus. Pediatr Res 11, 513 (1977). https://doi.org/10.1203/00006450-197704000-00860
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DOI: https://doi.org/10.1203/00006450-197704000-00860
