Abstract
Baseline glucose (Gl), insulin (Ins), glucagon (Glucag), cortisol (Cor) and alanine (Ala) determinations were drawn between 0-1 hours in 16 LBW infants (BW 1040-1490 gms. GA 29-34 wks.) after which an I.V. electrolyte-glucose (6 mg/kg/min.) infusion was begun. Repeat evaluations were done at 24 and 48 hrs.
The data were analyzed according to B.W., gestational age, 5 minute apgar score and appropriateness for gestational age. Significant findings were: glucose was ↑ in the group <1200 gms. at 24 hrs.(p=.05) and 48 hrs.(p=<.02). Insulin values in the apgar 1-5 group were ↑(p=<.05) at 24 hrs. coincident with a trend toward hyperglycemia. Alanine and glucagon levels were higher in all groups at 0-1 hrs. (p=<.01).
No significant correlation between glycemia, insulin or cortisol levels could be found. Hyperglycemia was present in the groups <1200 gms. The presence of initially elevated glucagon and alanine levels in the immediate perinatal period suggest that the LBW infant is capable of active gluconeogenesis.
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Ahmad, F., Beard, A., Boughter, J. et al. 829 HORMONAL VARIATION IN LBW INFANTS ON A CONSTANT GLUCOSE INFUSION. Pediatr Res 12 (Suppl 4), 502 (1978). https://doi.org/10.1203/00006450-197804001-00834
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DOI: https://doi.org/10.1203/00006450-197804001-00834
