Abstract
The hospital course of 60 premature infants with massive ICH were reviewed and compared to 60 controls matched for sex, birth weight, gestational age and date of birth. Intrapartum complications (p<.01), complicated delivery (p<.05), low Apgar score (p<.05) and hyaline membrane disease (p<.0005) were all seen more commonly in the ICH patients.
37/60 patients with ICH had a recorded blood sugar ≥ 200 mg/dl while only 10/60 controls showed that level of hyperglycemia (X2= 21.9, p<.0001). Glucose infusion rates at the time of the highest recorded blood sugar correlated weakly with the highest recorded blood sugar in the control group (.06>r>.05) and not at all in the ICH group.
The mean glucose infusion rate of the hyperglycemic (≥ 200 mg/dl) control patients (9.8 ± 1.2 mg/kg/min) was significantly higher than that of the normoglycemic controls (6.9 ± 1.0 mg/kg/min) (p<.05). The mean glucose infusion rate of the hyperglycemic ICH patients (7.6 ± 0.5 mg/kg/min) was not significantly different from that of the normoglycemic ICH patients (8.2 ± 1.9 mg/kg/min).
Glucose intolerance was not related to the site of ICH found at autopsy.
We conclude that sudden glucose intolerance in a premature infant may be a sign of massive intracranial hemorrhage.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cepeda, E., Heilbronner, D. & Poland, R. 943 GLUCOSE INTOLERANCE IN PREMATURE INFANTS WITH MASSIVE INTRACRANIAL HEMORRHAGE (ICH). Pediatr Res 12 (Suppl 4), 521 (1978). https://doi.org/10.1203/00006450-197804001-00949
Issue date:
DOI: https://doi.org/10.1203/00006450-197804001-00949
