Abstract
We have investigated the role of changes in RCRC (independent of Na intake) in determining susceptibility to ARF. RCRC was altered in either direction from control (Grp A - normal Na intake) in S.D. rats by 1% NaCl drinking + S.Q. DOCA for 4 wks (Grp B) or by a low Na diet for 6 wks (Grp C). For the next 5 days the animals were continued on the previous Na intake (Grp B1 & C1),normal Na intake (Grp B2 & C2), or 1% NaCl (Grp C3). On the 5th day the 24 hour urinary Na, C1 and Osm excretions were determined and random members from each group were sacrificed for RCRC determination. ARF was induced in the rest by injection of 10 mg/kg of 50% glycerol. Tail vein BUN's were done; results are shown (mean ± SEM). The number of animals in parenthesis.
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Bidani, A., Churchill, P., Fleischmann, L. et al. 1051 LACK OF A ROLE FOR RENAL RENIN (RCRC) IN DETERMINING SUSCEPTIBILITY TO MYOGLOBINURIC RENAL FAILURE (ARF) IN THE ABSENCE OF CHANGES IN Na INTAKE. Pediatr Res 12 (Suppl 4), 539 (1978). https://doi.org/10.1203/00006450-197804001-01057
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DOI: https://doi.org/10.1203/00006450-197804001-01057
