1078 EFFECT OF PGE₂ (P) ON NEONATAL RENAL FUNCTION

Abstract

Various hypotheses have been put forth regarding the role of prostaglandins (PS) on renal blood flow (RBF) and sodium balance during ontogeny. The inability to excrete a sodium load has been attributed in part to low renal PS and juxtamedullary blood flow distribution in the newborn kidneys. We studied the effect of P on RBF and renal function in 1 and 6 wk old puppies. The femoral vein, artery and ureters were catheterized under anesthesia. Glomerular filteration rate (GFR ml/min), PAH clearance (C_PAH), fractional excretion of sodium (FE_Na%) and urinary volume (V ml/min) were determined, before (C) and after (E) a bolus injection of P (30 μg/kg/BW), into the left renal artery. In addition in 1 wk old puppies microspheres were used to study RBF and cortical zonal distribution during C and E period. Intrarenal P injection increased V from 0.05 to 0.08 and from 0.06 to 0.09 in 1 and 6 wk old animals respectively. There were no changes in GFR in 1 wk and 6 wk old animals. C_PAH decreased in both groups but was significant only in 1 wk old animals^* (1 wk C 4.7±0.5 to 3.0±0.1, 6 wk C 18±3 to E 13±4). FE_Na increased 3-fold in 6 wks^* and 1.5-fold in 1 wk. Despite a 50% decline in RBF there were no changes in cortical zonal distribution of RBF following P injection, in 1 wk old puppies. These results suggest: 1) The lack of P is not responsible for the neonatal pattern of RBF. 2) Neonatal kidneys are less sensitive to exogenous P induced natriuresis ^*(P<.05).

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