Abstract
To determine whether the elevated glomerular filtration rates (GFR) and renal plasma flow (RPF) described early in the course of diabetes results from renal vasodilation or an increase in functioning mass, we examined the renal and systemic responses to a renal vasodilator, dopamine, in 10 juvenile diabetic (JDM) (ages 10-23 years), and compared the results to those observed in 10 patients (ages 11-30) who had recovered from an episode of acute poststreptococcal glomerulonephritis (PSGN). The mean pre-infusion values for GFR in JDM were 146 ml/min, RPF 763 ml/min, mean arterial pressure (MAP) 89 mm Hg and renal resistance (RT) 5563 d/sec/cm−5. In PSGN mean values for GFR were 124 ml/min, RPF 645 ml/min, MAP 88 mmHg and RT 6797 d/sec/cm−5.
In response to dopamine, the diabetics sustained a lesser increase in CIN and CPAH and a greater increase in MAP. No change in RT occurred in the diabetics, while a decrease of 25% was induced in the PSGN group. Our data confirm that renal hemodynamics are enhanced in young diabetics. Failure of renal resistance to decrease during administration of dopamine supports the thesis that an already vasodilated kidney is responsible for supernormal renal perfusion in these diabetics. The greater increase in MAP during dopamine suggest also a lesser vasodilatory response of the systemic resistance vessels in juvenile diabetes.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schacht, R., Baldwin, D. 1102 FAILURE OF THE KIDNEY TO VASODILATE IN DIABETES MELLITUS. Pediatr Res 12 (Suppl 4), 547 (1978). https://doi.org/10.1203/00006450-197804001-01108
Issue date:
DOI: https://doi.org/10.1203/00006450-197804001-01108
