Abstract
Currently available information on the perinatal and neonatal factors associated with cerebral intraventricular hemorrhage (CVH) in the preterm infant is based only on autopsy studies. In an attempt to identify which factors are associated with CVH in preterm infants, we have developed a multivariant model derived from 100 consecutive infants with birthweights ≤1500 grams who were admitted to the newborn intensive care unit. All 100 infants had a computed tomography (CT) brain scan performed within the first seven postnatal days to determine which of the infants had CVH.
Fifty perinatal and/or neonatal factors were analyzed. With the use of discriminant analysis, we have been able to determine the six most important factors associated with CVH. These factors are: sex(male), birthweight (900-1200 grams), one minute APGAR score (<4), Idiopathic Respiratory Distress Syndrome (IRDS), multiple gestation, and neonatal transport.
Application of this mathematical model to infants with birthweights ≤1500 grams gives the probability of CVH in an individual infant and identifies those infants who are at greatest risk for CVH.
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Papile, L., Skipper, B. 1145 CEREBRAL INTRAVENTRICULAR HEMORRHAGE: A MULTIVARIANT MODEL. Pediatr Res 12 (Suppl 4), 554 (1978). https://doi.org/10.1203/00006450-197804001-01151
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DOI: https://doi.org/10.1203/00006450-197804001-01151
